Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD).

Hyperglycemia induces key genetic and phenotypic changes in human liver epithelial HepG2 cells which parallel the Leprdb/J mouse model of non-alcoholic fatty liver disease (NAFLD).

Non-alcoholic fatty liver disease (NAFLD) is a growing global health concern. With a propensity to progress towards non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma, NAFLD is an important link amongst a multitude of comorbidities including obesity, diabetes, and cardiova...

Full description

Bibliographic Details
Main Authors: Robin C Su, Apurva Lad, Joshua D Breidenbach, Thomas M Blomquist, William T Gunning, Prabhatchandra Dube, Andrew L Kleinhenz, Deepak Malhotra, Steven T Haller, David J Kennedy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0225604

Internet

https://doi.org/10.1371/journal.pone.0225604

Similar Items