The Combined Effect of Retinoic Acid and LSD1 siRNA Inhibition on Cell Death in the Human Neuroblastoma Cell Line SH-SY5Y

The Combined Effect of Retinoic Acid and LSD1 siRNA Inhibition on Cell Death in the Human Neuroblastoma Cell Line SH-SY5Y

Aims: Retinoic acid (RA) is used pharmacologically to treat neuroblastoma (NB), but its mechanism of action is unclear and it has limited use against refractory disease. This study investigated the expression of LSD1 (also known as KDM1A) in tumors, and assessed the efficacy of combining RA treatmen...

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Bibliographic Details
Main Authors: Guofeng Xu, Yongtao Xiao, Jimeng Hu, Lili Xing, Ou Zhao, Yeming Wu
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2013-06-01
Series:Cellular Physiology and Biochemistry
Subjects:
Neuroblastoma
Retinoic acid
Lysine-specific demethylase 1
Apoptosis
SH-SY5Y cell line
Online Access:http://www.karger.com/Article/FullText/350103

Internet

http://www.karger.com/Article/FullText/350103

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