Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Development of NASH in Obese Mice is Confounded by Adipose Tissue Increase in Inflammatory NOV and Oxidative Stress

Aim. Nonalcoholic steatohepatitis (NASH) is the consequence of insulin resistance, fatty acid accumulation, oxidative stress, and lipotoxicity. We hypothesize that an increase in the inflammatory adipokine NOV decreases antioxidant Heme Oxygenase 1 (HO-1) levels in adipose and hepatic tissue, result...

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Bibliographic Details
Main Authors: David Sacerdoti, Shailendra P. Singh, Joseph Schragenheim, Lars Bellner, Luca Vanella, Marco Raffaele, Aliza Meissner, Ilana Grant, Gaia Favero, Rita Rezzani, Luigi F. Rodella, David Bamshad, Edward Lebovics, Nader G. Abraham
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:International Journal of Hepatology
Online Access:http://dx.doi.org/10.1155/2018/3484107

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http://dx.doi.org/10.1155/2018/3484107

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