Proposal of Potent Inhibitors for a Bacterial Cell Division Protein FtsZ: Molecular Simulations Based on Molecular Docking and ab Initio Molecular Orbital Calculations

Proposal of Potent Inhibitors for a Bacterial Cell Division Protein FtsZ: Molecular Simulations Based on Molecular Docking and ab Initio Molecular Orbital Calculations

The inhibition of a bacterial cell division protein, filamentous temperature-sensitive Z (FtsZ), prevents the reproduction of <i>Mycobacteria</i>. To propose potent inhibitors of FtsZ, the binding properties of FtsZ with various derivatives of Zantrin ZZ3 were investigated at an electron...

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Bibliographic Details
Main Authors: Shohei Yamamoto, Ryosuke Saito, Shunya Nakamura, Haruki Sogawa, Pavel Karpov, Sergey Shulga, Yaroslav Blume, Noriyuki Kurita
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Antibiotics
Subjects:
FtsZ
<i>Mycobacterium tuberculosis</i>
Zantrin
inhibitors
fragment molecular orbital
protein–ligand docking
Online Access:https://www.mdpi.com/2079-6382/9/12/846

Internet

https://www.mdpi.com/2079-6382/9/12/846

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