Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production

Immune inhibitory function of bovine CTLA-4 and the effects of its blockade in IFN-γ production

Abstract Background Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is known as an immune inhibitory receptor that is expressed on activated effector T cells and regulatory T cells. When CTLA-4 binds to CD80 or CD86, immunoinhibitory signals are transmitted to retain a homeostasis of the immune response....

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Bibliographic Details
Main Authors: Kei Watari, Satoru Konnai, Naoya Maekawa, Tomohiro Okagawa, Yasuhiko Suzuki, Shiro Murata, Kazuhiko Ohashi
Format: Article
Language:English
Published: BMC 2019-10-01
Series:BMC Veterinary Research
Subjects:
Cattle
CTLA-4
CD80
CD86
IFN-γ
BLV
Online Access:http://link.springer.com/article/10.1186/s12917-019-2082-7

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http://link.springer.com/article/10.1186/s12917-019-2082-7

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