Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children

Genome-Wide Association Meta-Analysis of Single-Nucleotide Polymorphisms and Symptomatic Venous Thromboembolism during Therapy for Acute Lymphoblastic Leukemia and Lymphoma in Caucasian Children

Symptomatic venous thromboembolism (VTE) occurs in five percent of children treated for acute lymphoblastic leukemia (ALL), but whether a genetic predisposition exists across different ALL treatment regimens has not been well studied. Methods: We undertook a genome-wide association study (GWAS) meta...

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Bibliographic Details
Main Authors: Marion K. Mateos, Morten Tulstrup, Michael CJ Quinn, Ruta Tuckuviene, Glenn M. Marshall, Ramneek Gupta, Chelsea Mayoh, Benjamin O. Wolthers, Pasquale M. Barbaro, Ellen Ruud, Rosemary Sutton, Pasi Huttunen, Tamas Revesz, Sonata S. Trakymiene, Draga Barbaric, Ulf Tedgård, Jodie E. Giles, Frank Alvaro, Olafur G. Jonsson, Françoise Mechinaud, Kadri Saks, Daniel Catchpoole, Rishi S. Kotecha, Luciano Dalla-Pozza, Georgia Chenevix-Trench, Toby N. Trahair, Stuart MacGregor, Kjeld Schmiegelow
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cancers
Subjects:
acute lymphoblastic leukemia
child
genome-wide association study
single-nucleotide polymorphism
venous thromboembolism
Online Access:https://www.mdpi.com/2072-6694/12/5/1285

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https://www.mdpi.com/2072-6694/12/5/1285

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