The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor

The Caenorhabditis elegans Oxidative Stress Response Requires the NHR-49 Transcription Factor

The overproduction of reactive oxygen species (ROS) in cells can lead to the development of diseases associated with aging. We have previously shown that C. elegans BRAP-2 (Brca1 associated binding protein 2) regulates phase II detoxification genes such as gst-4, by increasing SKN-1 activity. Previo...

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Bibliographic Details
Main Authors: Queenie Hu, Dayana R. D’Amora, Lesley T. MacNeil, Albertha J. M. Walhout, Terrance J. Kubiseski
Format: Article
Language:English
Published: Oxford University Press 2018-12-01
Series:G3: Genes, Genomes, Genetics
Subjects:
C. elegans
NHR-49
oxidative stress
reactive oxygen species
SKN-1
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.118.200727

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http://g3journal.org/lookup/doi/10.1534/g3.118.200727

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