Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice

Seipin Deficiency Accelerates Heart Failure Due to Calcium Handling Abnormalities and Endoplasmic Reticulum Stress in Mice

Seipin deficiency can induce hypertrophic cardiomyopathy and heart failure, which often leads to death in humans. To explore the effects and the possible mechanisms of Seipin deficiency in myocardial remodeling, Seipin knockout (SKO) mice underwent transverse aortic constriction (TAC) for 12 weeks....

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Bibliographic Details
Main Authors: Xiaoyue Wu, Xuejing Liu, Huan Wang, Zihao Zhou, Chengzhi Yang, Zijian Li, Youyi Zhang, XiaoLu Shi, Ling Zhang, Yuhui Wang, Xunde Xian, George Liu, Wei Huang
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
seipin
diastolic heart failure
calcium handling
endoplasmic reticulum stress
SERCA2a
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.644128/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2021.644128/full

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