Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase

Semi-Quantitative Mass Spectrometry in AML Cells Identifies New Non-Genomic Targets of the EZH2 Methyltransferase

Alterations to the gene encoding the EZH2 (KMT6A) methyltransferase, including both gain-of-function and loss-of-function, have been linked to a variety of haematological malignancies and solid tumours, suggesting a complex, context-dependent role of this methyltransferase. The successful implementa...

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Bibliographic Details
Main Authors: Yordan Sbirkov, Colin Kwok, Amandeep Bhamra, Andrew J. Thompson, Veronica Gil, Arthur Zelent, Kevin Petrie
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
acute myeloid leukaemia
EZH2
mass spectrometry
methylation
eEF1A1
Online Access:https://www.mdpi.com/1422-0067/18/7/1440

Internet

https://www.mdpi.com/1422-0067/18/7/1440

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