Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids

Abstract Under hypoxic conditions, tumor cells undergo a series of adaptations that promote evolution of a more aggressive tumor phenotype including the activation of DNA damage repair proteins, altered metabolism, and decreased proliferation. Together these changes mitigate the negative impact of o...

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Bibliographic Details
Main Authors: Stephen Riffle, Rashmi S. Hegde
Format: Article
Language:English
Published: BMC 2017-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Hypoxia
Multicellular Tumor Spheroids
Metabolism
DNA Damage Repair
Proliferation
Cancer
Online Access:http://link.springer.com/article/10.1186/s13046-017-0570-9

Internet

http://link.springer.com/article/10.1186/s13046-017-0570-9

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