Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine.

Structural and functional diversity among Type III restriction-modification systems that confer host DNA protection via methylation of the N4 atom of cytosine.

We report a new subgroup of Type III Restriction-Modification systems that use m4C methylation for host protection. Recognition specificities for six such systems, each recognizing a novel motif, have been determined using single molecule real-time DNA sequencing. In contrast to all previously chara...

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Bibliographic Details
Main Authors: Iain A Murray, Yvette A Luyten, Alexey Fomenkov, Nan Dai, Ivan R Corrêa, William G Farmerie, Tyson A Clark, Jonas Korlach, Richard D Morgan, Richard J Roberts
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0253267

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https://doi.org/10.1371/journal.pone.0253267

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