Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2

Mutant three-repeat tau expression initiates retinal ganglion cell death through Caspase-2

The microtubule-associated protein tau is implicated in multiple degenerative diseases including retinal diseases such as glaucoma; however, the way tau initiates retinopathy is unclear. Previous retinal assessments in mouse models of tauopathy suggest that mutations in four-repeat (4R) tau are asso...

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Bibliographic Details
Main Authors: Jennifer Ngolab, Saranya Canchi, Suhail Rasool, Abderrahman Elmaarouf, Kimberly Thomas, Floyd Sarsoza, Jennifer Grundman, Michael Mante, Jazmin Florio, Nimisha Nandankar, Shaina Korouri, Wagner Zago, Eliezer Masliah, Robert A. Rissman
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Neurobiology of Disease
Subjects:
Retina
Tau
3 repeat tau
Retinopathy
Alzheimer's, tauopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121000267

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http://www.sciencedirect.com/science/article/pii/S0969996121000267

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