Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression.

Recent studies in human fibroblasts have provided a new general paradigm of tumor suppression according to which oncogenic signaling produces DNA damage and this, in turn, results in ATM/p53-dependent cellular senescence. Here, we have tested this model in a variety of murine experimental systems. O...

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Bibliographic Details
Main Authors: Alejo Efeyan, Matilde Murga, Barbara Martinez-Pastor, Ana Ortega-Molina, Rebeca Soria, Manuel Collado, Oscar Fernandez-Capetillo, Manuel Serrano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2675057?pdf=render

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http://europepmc.org/articles/PMC2675057?pdf=render

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