The human β-amyloid precursor protein: biomolecular and epigenetic aspects

The human β-amyloid precursor protein: biomolecular and epigenetic aspects

Beta-amyloid precursor protein (APP) is a membrane-spanning protein with a large extracellular domain and a much smaller intracellular domain. APP plays a central role in Alzheimer’s disease (AD) pathogenesis: APP processing generates β-amyloid (Aβ) peptides, which are deposited as amyloid plaques i...

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Bibliographic Details
Main Author: Nguyen Khue Vu
Format: Article
Language:English
Published: De Gruyter 2015-03-01
Series:Biomolecular Concepts
Subjects:
alzheimer’s disease
autism
β-amyloid precursor protein
β-amyloid (aβ) peptide
epigenetics
epistasis
fragile x syndrome
genomic rearrangenments
hgprt
lesch-nyhan syndrome
Online Access:https://doi.org/10.1515/bmc-2014-0041

Internet

https://doi.org/10.1515/bmc-2014-0041

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