TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma

TRPM7 Induces Tumorigenesis and Stemness Through Notch Activation in Glioma

We have reported that transient receptor potential melastatin-related 7 (TRPM7) regulates glioma stem cells (GSC) growth and proliferation through Notch, STAT3-ALDH1, and CD133 signaling pathways. In this study, we determined the major contributor(s) to TRPM7 mediated glioma stemness by further deci...

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Bibliographic Details
Main Authors: Jingwei Wan, Alyssa Aihui Guo, Pendelton King, Shanchun Guo, Talib Saafir, Yugang Jiang, Mingli Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-12-01
Series:Frontiers in Pharmacology
Subjects:
TRPM7
glioma
CD133
Aldehyde dehydrogenase 1
molecular targets
cell cycle
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.590723/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.590723/full

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