Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

Rhein Derivative 4F Inhibits the Malignant Phenotype of Breast Cancer by Downregulating Rac1 Protein

BackgroundTriple-negative breast cancer is a common malignant tumor with unfavorable prognosis affecting women worldwide; thus, there is an urgent need for novel therapeutic drugs with improved anti-tumor activity. Rac family small GTPase 1 (Rac1) plays an important role in malignant behavior and is...

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Bibliographic Details
Main Authors: Xinxiao Li, Yunfeng Liu, Yuhua Zhao, Wei Tian, Lina Zhai, Huifeng Pang, Jiankang Kang, Huaxin Hou, Yanhua Chen, Danrong Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Pharmacology
Subjects:
Rhein derivative
drug design
Rac family small GTPase 1
breast cancer
anticancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00754/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00754/full

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