The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression

Germline mutations of BRCA1 confer hereditary susceptibility to breast and ovarian cancer. However, somatic mutation of BRCA1 is infrequent in sporadic breast cancers. The BRCA1 protein C terminus (BRCT) domains interact with multiple proteins and are required for BRCA1’s tumor-suppressor function....

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Bibliographic Details
Main Authors: Andy Castillo, Atanu Paul, Baohua Sun, Ting Hsiang Huang, Yucai Wang, Stephanie A. Yazinski, Jessica Tyler, Lei Li, M. James You, Lee Zou, Jun Yao, Bin Wang
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714005348

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http://www.sciencedirect.com/science/article/pii/S2211124714005348

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