The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy

The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy

We have previously shown that mice heterozygously deficient for P0 are characterized by a late onset myelin disorder implicating CD8+ T-lymphocytes and macrophages. We now investigated the impact of the co-inhibitory molecule “programmed death” (PD)-1 (CD279), a CD28-related receptor expressed on ac...

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Bibliographic Details
Main Authors: Antje Kroner, Nicholas Schwab, Chi Wang Ip, Claudia Sommer, Carsten Wessig, Heinz Wiendl, Rudolf Martini
Format: Article
Language:English
Published: Elsevier 2009-01-01
Series:Neurobiology of Disease
Subjects:
Schwann cell
Charcot-Marie-Tooth disease
Myelin
T-lymphocytes
Adaptive immune system
Macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996108002301

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http://www.sciencedirect.com/science/article/pii/S0969996108002301

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