The co-inhibitory molecule PD-1 modulates disease severity in a model for an inherited, demyelinating neuropathy
We have previously shown that mice heterozygously deficient for P0 are characterized by a late onset myelin disorder implicating CD8+ T-lymphocytes and macrophages. We now investigated the impact of the co-inhibitory molecule “programmed death” (PD)-1 (CD279), a CD28-related receptor expressed on ac...
Main Authors: | Antje Kroner, Nicholas Schwab, Chi Wang Ip, Claudia Sommer, Carsten Wessig, Heinz Wiendl, Rudolf Martini |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2009-01-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996108002301 |
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