Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Inhibition of RORγT Skews TCRα Gene Rearrangement and Limits T Cell Repertoire Diversity

Recent studies have elucidated the molecular mechanism of RORγT transcriptional regulation of Th17 differentiation and function. RORγT was initially identified as a transcription factor required for thymopoiesis by maintaining survival of CD4+CD8+ (DP) thymocytes. While RORγ antagonists are currentl...

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Bibliographic Details
Main Authors: Yanxia Guo, Kenzie D. MacIsaac, Yi Chen, Richard J. Miller, Renu Jain, Barbara Joyce-Shaikh, Heidi Ferguson, I-Ming Wang, Razvan Cristescu, John Mudgett, Laura Engstrom, Kyle J. Piers, Gretchen A. Baltus, Kenneth Barr, Hongjun Zhang, Huseyin Mehmet, Laxminarayan G. Hegde, Xiao Hu, Laura L. Carter, Thomas D. Aicher, Gary Glick, Dennis Zaller, Abbas Hawwari, Craig C. Correll, Dallas C. Jones, Daniel J. Cua
Format: Article
Language:English
Published: Elsevier 2016-12-01
Series:Cell Reports
Subjects:
RORγT
small-molecule antagonist
thymopoiesis
T cell repertoire
autoimmunity
experimental autoimmune encephalomyelitis
experimental psoriasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716316473

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http://www.sciencedirect.com/science/article/pii/S2211124716316473

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