Genome-wide discovery of novel M1T1 group A streptococcal determinants important for fitness and virulence during soft-tissue infection.

The Group A Streptococcus remains a significant human pathogen causing a wide array of disease ranging from self-limiting to life-threatening invasive infections. Epithelium (skin or throat) colonization with progression to the subepithelial tissues is the common step in all GAS infections. Here, we...

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Main Authors: Yoann Le Breton, Ashton T Belew, Jeffrey A Freiberg, Ganesh S Sundar, Emrul Islam, Joshua Lieberman, Mark E Shirtliff, Hervé Tettelin, Najib M El-Sayed, Kevin S McIver
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-08-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5584981?pdf=render