CRISPR/Cas9 Genome Engineering in Engraftable Human Brain-Derived Neural Stem Cells
Summary: Human neural stem cells (NSCs) offer therapeutic potential for neurodegenerative diseases, such as inherited monogenic nervous system disorders, and neural injuries. Gene editing in NSCs (GE-NSCs) could enhance their therapeutic potential. We show that NSCs are amenable to gene targeting at...
Main Authors: | , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-05-01
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Series: | iScience |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004219301336 |