A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

A Two-Phase Expansion Protocol Combining Interleukin (IL)-15 and IL-21 Improves Natural Killer Cell Proliferation and Cytotoxicity against Rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in children. Despite intensive research in recent decades the prognosis for patients with metastatic or relapsed diseases has hardly improved. New therapeutic concepts in anti-tumor therapy aim to modulate the patient’s immune system t...

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Bibliographic Details
Main Authors: Juliane Wagner, Viktoria Pfannenstiel, Anja Waldmann, Judith W. J. Bergs, Boris Brill, Sabine Huenecke, Thomas Klingebiel, Franz Rödel, Christian J. Buchholz, Winfried S. Wels, Peter Bader, Evelyn Ullrich
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-06-01
Series:Frontiers in Immunology
Subjects:
natural killer cells
radiotherapy
rhabdomyosarcoma
RH30 cells
RD cells
interleukin-15
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00676/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.00676/full

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