The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy

The Kynurenic Acid Analog SZR72 Enhances Neuronal Activity after Asphyxia but Is Not Neuroprotective in a Translational Model of Neonatal Hypoxic Ischemic Encephalopathy

Hypoxic–ischemic encephalopathy (HIE) remains to be a major cause of long-term neurodevelopmental deficits in term neonates. Hypothermia offers partial neuroprotection warranting research for additional therapies. Kynurenic acid (KYNA), an endogenous product of tryptophan metabolism, was previously...

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Bibliographic Details
Main Authors: Viktória Kovács, Gábor Remzső, Tímea Körmöczi, Róbert Berkecz, Valéria Tóth-Szűki, Andrea Pénzes, László Vécsei, Ferenc Domoki
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
birth asphyxia
neonatal encephalopathy
newborn pig
therapeutic hypothermia
kynurenine
Online Access:https://www.mdpi.com/1422-0067/22/9/4822

Internet

https://www.mdpi.com/1422-0067/22/9/4822

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