Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo

Lactate Promotes Myoblast Differentiation and Myotube Hypertrophy via a Pathway Involving MyoD In Vitro and Enhances Muscle Regeneration In Vivo

Lactate is a metabolic substrate mainly produced in muscles, especially during exercise. Recently, it was reported that lactate affects myoblast differentiation; however, the obtained results are inconsistent and the in vivo effect of lactate remains unclear. Our study thus aimed to evaluate the eff...

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Bibliographic Details
Main Authors: Sakuka Tsukamoto, Ayako Shibasaki, Ayano Naka, Hazuki Saito, Kaoruko Iida
Format: Article
Language:English
Published: MDPI AG 2018-11-01
Series:International Journal of Molecular Sciences
Subjects:
lactate
muscle differentiation
fiber hypertrophy
MyoD
myosin heavy chain
Online Access:https://www.mdpi.com/1422-0067/19/11/3649

Internet

https://www.mdpi.com/1422-0067/19/11/3649

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