Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor

Computational Studies of a Mechanism for Binding and Drug Resistance in the Wild Type and Four Mutations of HIV-1 Protease with a GRL-0519 Inhibitor

Drug resistance of mutations in HIV-1 protease (PR) is the most severe challenge to the long-term efficacy of HIV-1 PR inhibitor in highly active antiretroviral therapy. To elucidate the molecular mechanism of drug resistance associated with mutations (D30N, I50V, I54M, and V82A) and inhibitor (GRL-...

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Bibliographic Details
Main Authors: Guodong Hu, Aijing Ma, Xianghua Dou, Liling Zhao, Jihua Wang
Format: Article
Language:English
Published: MDPI AG 2016-05-01
Series:International Journal of Molecular Sciences
Subjects:
MD simulation
MM-PBSA
HIV-1 PR
drug resistance
Online Access:http://www.mdpi.com/1422-0067/17/6/819

Internet

http://www.mdpi.com/1422-0067/17/6/819

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