A Heterozygous Mutation in Cardiac Troponin T Promotes Ca<sup>2+</sup> Dysregulation and Adult Cardiomyopathy in Zebrafish

A Heterozygous Mutation in Cardiac Troponin T Promotes Ca<sup>2+</sup> Dysregulation and Adult Cardiomyopathy in Zebrafish

Cardiomyopathies are a group of heterogeneous diseases that affect the muscles of the heart, leading to early morbidity and mortality in young and adults. Genetic forms of cardiomyopathy are caused predominantly by mutations in structural components of the cardiomyocyte sarcomeres, the contractile u...

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Bibliographic Details
Main Authors: Sarah M. Kamel, Charlotte D. Koopman, Fabian Kruse, Sven Willekers, Sonja Chocron, Jeroen Bakkers
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Journal of Cardiovascular Development and Disease
Subjects:
cardiac Troponin T
cardiomyopathy
zebrafish
structural remodeling
calcium dysregulation
contractility defects
Online Access:https://www.mdpi.com/2308-3425/8/4/46

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https://www.mdpi.com/2308-3425/8/4/46

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