Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function.

microRNAs (miRNAs) are critical to heart development and disease. Emerging research indicates that regulated precursor processing can give rise to an unexpected diversity of miRNA variants. We subjected small RNA from murine HL-1 cardiomyocyte cells to next generation sequencing to investigate the r...

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Bibliographic Details
Main Authors: David T Humphreys, Carly J Hynes, Hardip R Patel, Grace H Wei, Leah Cannon, Diane Fatkin, Catherine M Suter, Jennifer L Clancy, Thomas Preiss
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3272019?pdf=render