Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists

Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization, and use of a vertebrate ‘insulin-free’ model to identify insulin-independent modulators of glucose metabolism. insul...

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Bibliographic Details
Main Authors: Sri Teja Mullapudi, Christian SM Helker, Giulia LM Boezio, Hans-Martin Maischein, Anna M Sokol, Stefan Guenther, Hiroki Matsuda, Stefan Kubicek, Johannes Graumann, Yu Hsuan Carol Yang, Didier YR Stainier
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
glucose homeostasis
insulin
drug screen
androgen
transplantation
Online Access:https://elifesciences.org/articles/42209

Internet

https://elifesciences.org/articles/42209

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