Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

Depletion of phosphatidylcholine affects endoplasmic reticulum morphology and protein traffic at the Golgi complex

The mutant Chinese hamster ovary cell line MT58 contains a thermosensitive mutation in CTP:phosphocholine cytidylyltransferase, the regulatory enzyme in the CDP-choline pathway. As a result, MT58 cells have a 50% decrease in their phosphatidylcholine (PC) level within 24 h when cultured at the nonpe...

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Bibliographic Details
Main Authors: Nicole Testerink, Michiel H.M. van der Sanden, Martin Houweling, J. Bernd Helms, Arie B. Vaandrager
Format: Article
Language:English
Published: Elsevier 2009-11-01
Series:Journal of Lipid Research
Subjects:
CTP:phosphocholine cytidylyltransferase
lipid droplets
protein transport
diacylglycerol
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520306842

Internet

http://www.sciencedirect.com/science/article/pii/S0022227520306842

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