Sox2 Suppresses Gastric Tumorigenesis in Mice

Sox2 expression marks gastric stem and progenitor cells, raising important questions regarding the genes regulated by Sox2 and the role of Sox2 itself during stomach homeostasis and disease. By using ChIP-seq analysis, we have found that the majority of Sox2 targets in gastric epithelial cells are t...

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Bibliographic Details
Main Authors: Abby Sarkar, Aaron J. Huebner, Rita Sulahian, Anthony Anselmo, Xinsen Xu, Kyle Flattery, Niyati Desai, Carlos Sebastian, Mary Anna Yram, Katrin Arnold, Miguel Rivera, Raul Mostoslavsky, Roderick Bronson, Adam J. Bass, Ruslan Sadreyev, Ramesh A. Shivdasani, Konrad Hochedlinger
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716309524