Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation.

BACKGROUND: Mast cells (MCs) have long been suspected as important players for implantation based on the fact that their degranulation causes the release of pivotal factors, e.g., histamine, MMPs, tryptase and VEGF, which are known to be involved in the attachment and posterior invasion of the embry...

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Bibliographic Details
Main Authors: Federico Jensen, Mariana Woudwyk, Ana Teles, Katja Woidacki, Florin Taran, Serban Costa, Sara Fill Malfertheiner, Ana Claudia Zenclussen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3008683?pdf=render