The strategy for enhancing temozolomide against malignant glioma

The strategy for enhancing temozolomide against malignant glioma

A combined therapy of the alkylating agent temozolomide (TMZ) and radiotherapy is standard treatment, and it improves the survival of patients with newly diagnosed glioblastoma (GBM). The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) removes the most cytotoxic lesions generated by...

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Bibliographic Details
Main Authors: Mitsutoshi eNakada, Takuya eFuruta, Yutaka eHayashi, Toshinari eMinamoto, Jun-ichiro eHamada
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-08-01
Series:Frontiers in Oncology
Subjects:
Glioma
Valproic Acid
resveratrol
chemosensitivity
interferon-β
levetiracetam
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00098/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00098/full

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