Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs

Hypoosmotic conditions activate volume-regulated anion channels in vertebrate cells. These channels are formed by leucine-rich repeat-containing protein 8 (LRRC8) family members and contain LRRC8A in homo- or hetero-hexameric assemblies. Here, we present single-particle cryo-electron microscopy stru...

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Bibliographic Details
Main Authors: David M Kern, SeCheol Oh, Richard K Hite, Stephen G Brohawn
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-02-01
Series:eLife
Subjects:
VRAC
LRRC8
volume regulation
cryo-EM
ion channel
Online Access:https://elifesciences.org/articles/42636

Internet

https://elifesciences.org/articles/42636

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