Bioflavonoid ellagic acid inhibits aldose reductase: Implications for prevention of diabetic complications

Bioflavonoid ellagic acid inhibits aldose reductase: Implications for prevention of diabetic complications

Accumulation of intracellular sorbitol due to increased aldose reductase (AR or ALR2) activity is one of the pathways implicated in the development of long-term diabetic complications. In the present study, we described the inhibition of ALR2 by ellagic acid (EA), a bioflavonoid present in many diet...

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Bibliographic Details
Main Authors: Chandrasekhar Akileshwari, Ganugula Raghu, Puppala Muthenna, Niklaus H. Mueller, Palla Suryanaryana, J. Mark Petrash, G. Bhanuprakash Reddy
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Journal of Functional Foods
Subjects:
Aldose reductase
Aldehyde reductase
Diabetic cataract
Ellagic acid
Lens opacity
Sorbitol
Online Access:http://www.sciencedirect.com/science/article/pii/S1756464613002582

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http://www.sciencedirect.com/science/article/pii/S1756464613002582

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