Mammary epithelium‐specific inactivation of V‐ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer

Mammary epithelium‐specific inactivation of V‐ATPase reduces stiffness of extracellular matrix and enhances metastasis of breast cancer

Extracellular matrix (ECM) critically impacts tumor progression and is influenced by both cancer and host tissue cells. While our understanding of cancer cell ECM remodeling is widespread, the importance of host tissue ECM, which provides initial congenial environment for primary tumor formation, is...

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Bibliographic Details
Main Authors: Gajendra K. Katara, Arpita Kulshrestha, Liqun Mao, Xin Wang, Manoranjan Sahoo, Safaa Ibrahim, Sahithi Pamarthy, Kimiko Suzue, Gajendra S. Shekhawat, Alice Gilman‐Sachs, Kenneth D. Beaman
Format: Article
Language:English
Published: Wiley 2018-02-01
Series:Molecular Oncology
Subjects:
atomic force microscopy
ATP6V0a2
breast cancer metastasis
extracellular matrix stiffness
glycosylation
V‐ATPase
Online Access:https://doi.org/10.1002/1878-0261.12159

Internet

https://doi.org/10.1002/1878-0261.12159

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