Nitric Oxide Synthase Type III Overexpression By Gene Therapy Exerts Antitumoral Activity In Mouse Hepatocellular Carcinoma

Nitric Oxide Synthase Type III Overexpression By Gene Therapy Exerts Antitumoral Activity In Mouse Hepatocellular Carcinoma

Hepatocellular carcinoma develops in cirrhotic liver. The nitric oxide (NO) synthase type III (NOS-3) overexpression induces cell death in hepatoma cells. The study developed gene therapy designed to specifically overexpress NOS-3 in cultured hepatoma cells, and in tumors derived from orthotopically...

Full description

Bibliographic Details
Main Authors:	Raúl González, Ángel J. De la Rosa, Santiago Romero-Brufau, Lydia Barrera-Pulido, Francisco Gallardo-Chamizo, Sheila Pereira, Luís M. Marín, José M. Álamo, Ángeles Rodríguez-Hernández, Francisco J. Padillo, Jordi Muntané
Format:	Article
Language:	English
Published:	Elsevier 2015-08-01
Series:	Redox Biology
Online Access:	http://www.sciencedirect.com/science/article/pii/S2213231715001433

Similar Items

Overexpression of Inducible Nitric Oxide Synthase in Allergic and Nonallergic Nasal Polyp
by: Ahmed Adel Sadek, et al.
Published: (2019-01-01)

Phenotype of transgenic mice overexpressed with inducible nitric oxide synthase in the retina.
by: Guey Shuang Wu, et al.
Published: (2012-01-01)

Nitric oxide synthase inhibition enhances the antitumor effect of radiation in the treatment of squamous carcinoma xenografts.
by: Robert J G Cardnell, et al.
Published: (2011-01-01)

Overexpression of endothelial nitric oxide synthase suppresses features of allergic asthma in mice
by: De Clerck Fred, et al.
Published: (2006-04-01)

Overexpression of Rat Neurons Nitric Oxide Synthase in Rice Enhances Drought and Salt Tolerance.
by: Wei Cai, et al.
Published: (2015-01-01)

Does Melatonin Exert Its Effect on Ram Sperm Capacitation Through Nitric Oxide Synthase Regulation?
by: Sara Miguel-Jiménez, et al.
Published: (2020-03-01)

Aloperine Exerts Antitumor Effects on Bladder Cancer in vitro
by: Zhang L, et al.
Published: (2020-10-01)

Overexpression of endothelial nitric oxide synthase and mitochondrial superoxide dismutase in the rostral ventrolateralmedulla in central cardiovascular regulation
by: Ling-chang Kung, et al.
Published: (2005)

Nitric Oxide synthases and atrial fibrillation
by: Ingrid M Bonilla, et al.
Published: (2012-04-01)

Predictive value and changes of inducible nitric oxide synthase expression in patients with rectal cancer under the influence of antitumor therapy
by: V. V. Holotiuk, et al.
Published: (2018-09-01)

BACTERIAL NITRIC OXIDE SYNTHASE
by: Б. М. Галкін, et al.
Published: (2011-09-01)

Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice
by: Masato Tsutsui, et al.
Published: (2015-01-01)

Juglone exerts antitumor effect in ovarian cancer cells
by: Fang Fang, et al.
Published: (2015-06-01)

Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma
by: Satoshi Miyagaki, et al.
Published: (2021-09-01)

Differential Antitumoral Properties and Renal-Associated Tissue Damage Induced by Tacrolimus and Mammalian Target of Rapamycin Inhibitors in Hepatocarcinoma: In Vitro and In Vivo Studies.
by: Elena Navarro-Villarán, et al.
Published: (2016-01-01)

Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
by: Rosekeila Simões Nomelini, et al.
Published: (2008-01-01)

Nitric Oxide Synthase Simple Enzyme-Complex Roles
Published: (2017)

Repeated Nitrous Oxide Exposure Exerts Antidepressant-Like Effects Through Neuronal Nitric Oxide Synthase Activation in the Medial Prefrontal Cortex
by: Wei Liu, et al.
Published: (2020-09-01)

Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances
by: Chiara De Luca, et al.
Published: (2015-01-01)

Signalübertragungswege und Präventionsmöglichkeiten der kardialen Hypertrophie : conditional overexpression of neuronal nitric oxide synthase is cardioprotective in ischemia-reperfusion
by: Burkard, Natalie
Published: (2010)

Incarcerated Spigelian hernia: Diagnosis by computed tomography Hernia de Spiegel incarcerada: diagnóstico por TAC
by: Adolfo Cruz, et al.
Published: (2012-12-01)

Wiring Inducible Nitric Oxide Synthase
by: Nguyen, Yen Hoang Le
Published: (2007)

Nitric Oxide Synthase Inhibitors as Antidepressants
by: Vallo Volke, et al.
Published: (2010-01-01)

Regulation of inducible nitric oxide synthase
by: Feng, Gui-jie
Published: (1997)

Biomimetic models for nitric oxide synthase
by: Pluciennick, Cecile
Published: (2002)

A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage
by: Nevzat Selim Gokay, et al.
Published: (2016-01-01)

Characterisation of nitric oxide synthase isoforms and nitric oxide synthase activity in human breast cancer cell lines
by: Lahiri, Mayurika
Published: (2001)

MicroRNA‐9 exerts antitumor effects on hepatocellular carcinoma progression by targeting HMGA2
by: Xiangang Xu, et al.
Published: (2019-10-01)

Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells.
by: Song Zhang, et al.
Published: (2013-01-01)

Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies
by: Elliott, J., et al.
Published: (2022)

Antitumoral Activity Of Nitric Oxide-Releasing Compounds
by: Magdalena Klink, et al.
Published: (2015-08-01)

Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
by: Yasuko Iwakiri
Published: (2015-12-01)

Role of nitric oxide and nitric oxide synthases in the rice blast fungus
by: Illes, Mary
Published: (2008)

Transplantation of adipose-derived stem cells overexpressing inducible nitric oxide synthase ameliorates diabetes mellitus-induced erectile dysfunction in rats
by: Yan Zhang, et al.
Published: (2019-08-01)

Role of nitric oxide and endothelial NO synthase in carcinogenesis
by: V. P. Deryagina, et al.
Published: (2021-07-01)

Nitric oxide synthase and polycystic kidney disease
by: Wiwanitkit Viroj
Published: (2015-04-01)

Alterations in Nitric Oxide Synthase in the Aged CNS
by: Junyang Jung, et al.
Published: (2012-01-01)

Targeting and translocation of endothelial nitric oxide synthase
by: T. Michel
Published: (1999-11-01)

Neuronal nitric oxide synthase and affective disorders
by: Qi-Gang Zhou, et al.
Published: (2018-12-01)

Modulation of nitric oxide synthase activity in macrophages
by: P. G. Jorens, et al.
Published: (1995-01-01)