Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice

Physiological competition of brain phenylalanine accretion: Initial pharmacokinetic analyses of aminoisobutyric and methylaminoisobutyric acids in Pahenu2−/− mice

Objective: Initial studies on the use of non-physiological amino acids (NPAAs) to block the accretion of Phe in the brain of Pahenu2−/− mice revealed that 2-aminoisobutyrate (AIB) and N-methyl-2-aminoisobutyrate (MAIB) were promising lead compounds whose pharmacokinetic parameters warranted investig...

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Bibliographic Details
Main Authors: Kara R. Vogel, Garrett R. Ainslie, Brian Phillips, Erland Arning, Teodoro Bottiglieri, Danny D. Shen, K. Michael Gibson
Format: Article
Language:English
Published: Elsevier 2015-06-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Phenylketonuria
Large neutral amino acids
Phenylalanine
LAT-1 transporter
Aminoisobutyric acid
Methylaminoisobutyric acid
Pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426915300021

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http://www.sciencedirect.com/science/article/pii/S2214426915300021

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