Tumor vascular permeability to a nanoprobe correlates to tumor-specific expression levels of angiogenic markers.

BACKGROUND: Vascular endothelial growth factor (VEGF) receptor-2 is the major mediator of the mitogenic, angiogenic, and vascular hyperpermeability effects of VEGF on breast tumors. Overexpression of VEGF and VEGF receptor-2 is associated with the degree of pathomorphosis of the tumor tissue and unf...

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Bibliographic Details
Main Authors: Efstathios Karathanasis, Leslie Chan, Lohitash Karumbaiah, Kathleen McNeeley, Carl J D'Orsi, Ananth V Annapragada, Ioannis Sechopoulos, Ravi V Bellamkonda
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2009-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2688084?pdf=render