Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo.
Notch signalling is a fundamental pathway that shapes the developing embryo and sustains adult tissues by direct communication between ligand and receptor molecules on adjacent cells. Among the ligands are two Delta paralogues, DLL1 and DLL4, that are conserved in mammals and share a similar structu...
Main Authors: | Kristina Preuße, Lena Tveriakhina, Karin Schuster-Gossler, Cláudia Gaspar, Alexandra Isabel Rosa, Domingos Henrique, Achim Gossler, Michael Stauber |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2015-06-01
|
Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC4482573?pdf=render |
Similar Items
-
The ectodomains determine ligand function in vivo and selectivity of DLL1 and DLL4 toward NOTCH1 and NOTCH2 in vitro
by: Lena Tveriakhina, et al.
Published: (2018-10-01) -
Activity of the mouse Notch ligand DLL1 is sensitive to C-terminal tagging in vivo
by: Karin Schuster-Gossler, et al.
Published: (2021-09-01) -
Normal development in mice over-expressing the intracellular domain of DLL1 argues against reverse signaling by DLL1 in vivo.
by: Christian Redeker, et al.
Published: (2013-01-01) -
O-fucosylation of the notch ligand mDLL1 by POFUT1 is dispensable for ligand function.
by: Julia Müller, et al.
Published: (2014-01-01) -
O-fucosylation of DLL3 is required for its function during somitogenesis.
by: Katrin Serth, et al.
Published: (2015-01-01)