Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice

SUMMARY Mutations in SPG4, encoding the microtubule-severing protein spastin, are responsible for the most frequent form of hereditary spastic paraplegia (HSP), a heterogeneous group of genetic diseases characterized by degeneration of the corticospinal tracts. We previously reported that mice harbo...

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Main Authors: Coralie Fassier, Anne Tarrade, Leticia Peris, Sabrina Courageot, Philippe Mailly, Cécile Dalard, Stéphanie Delga, Natacha Roblot, Julien Lefèvre, Didier Job, Jamilé Hazan, Patrick A. Curmi, Judith Melki
Format: Article
Language:English
Published: The Company of Biologists 2013-01-01
Series:Disease Models & Mechanisms
Online Access:http://dmm.biologists.org/content/6/1/72

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http://dmm.biologists.org/content/6/1/72

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