The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

The longevity gene mIndy (I’m Not Dead, Yet) affects blood pressure through sympathoadrenal mechanisms

Reduced expression of the plasma membrane citrate transporter INDY (acronym I’m Not Dead, Yet) extends life span in lower organisms. Deletion of the mammalian Indy (mIndy) gene in rodents improves metabolism via mechanisms akin to caloric restriction, known to lower blood pressure (BP) by sympathoad...

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Bibliographic Details
Main Authors: Diana M. Willmes, Martin Daniels, Anica Kurzbach, Stefanie Lieske, Nicole Bechmann, Tina Schumann, Christine Henke, Nermeen N. El-Agroudy, Andrey C. Da Costa Goncalves, Mirko Peitzsch, Anja Hofmann, Waldemar Kanczkowski, Kristin Kräker, Dominik N. Müller, Henning Morawietz, Andreas Deussen, Michael Wagner, Ali El-Armouche, Stephen L. Helfand, Stephan R. Bornstein, Rafael de Cabo, Michel Bernier, Graeme Eisenhofer, Jens Tank, Jens Jordan, Andreas L. Birkenfeld
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-01-01
Series:JCI Insight
Subjects:
Metabolism
Vascular biology
Online Access:https://doi.org/10.1172/jci.insight.136083

Internet

https://doi.org/10.1172/jci.insight.136083

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