Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration
Abstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2021-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-94055-1 |
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Article |
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DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam |
| spellingShingle |
Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration Scientific Reports |
| author_facet |
Jennifer K. Frediani Joshua M. Levy Anuradha Rao Leda Bassit Janet Figueroa Miriam B. Vos Anna Wood Robert Jerris Van Leung-Pineda Mark D. Gonzalez Beverly B. Rogers Maud Mavigner Raymond F. Schinazi Nils Schoof Jesse J. Waggoner Russell R. Kempker Paulina A. Rebolledo Jared W. O’Neal Cheryl Stone Ann Chahroudi Claudia R. Morris Allie Suessmith Julie Sullivan Sarah Farmer Amanda Foster John D. Roback Thanuja Ramachandra CaDeidre Washington Kristie Le Maria C. Cordero Annette Esper Eric J. Nehl Yun F. Wang Erika A. Tyburski Greg S. Martin Wilbur A. Lam |
| author_sort |
Jennifer K. Frediani |
| title |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_short |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_full |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_fullStr |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_full_unstemmed |
Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| title_sort |
multidisciplinary assessment of the abbott binaxnow sars-cov-2 point-of-care antigen test in the context of emerging viral variants and self-administration |
| publisher |
Nature Publishing Group |
| series |
Scientific Reports |
| issn |
2045-2322 |
| publishDate |
2021-07-01 |
| description |
Abstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as “self-tests”. Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B.1.1.7 (Alpha) first identified in the UK, B.1.351 (Beta) first identified in South Africa, P.1 (Gamma) first identified in Brazil, B.1.617.2 (Delta) first identified in India and B.1.2, a non-VOC, test sensitivity decreased with decreasing viral loads. Moreover, BinaxNOW sensitivity trended lower when devices were performed by patients/caregivers themselves compared to trained clinical staff, despite universally high usability assessments following self/caregiver-administration among different age groups. Overall, these data indicate that while BinaxNOW accurately detects the new viral variants, as rapid COVID-19 tests enter the home, their already lower sensitivities compared to RT-PCR may decrease even more due to user error. |
| url |
https://doi.org/10.1038/s41598-021-94055-1 |
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doaj-30016094be9f470888a58161d2407fd52021-07-18T11:24:29ZengNature Publishing GroupScientific Reports2045-23222021-07-011111910.1038/s41598-021-94055-1Multidisciplinary assessment of the Abbott BinaxNOW SARS-CoV-2 point-of-care antigen test in the context of emerging viral variants and self-administrationJennifer K. Frediani0Joshua M. Levy1Anuradha Rao2Leda Bassit3Janet Figueroa4Miriam B. Vos5Anna Wood6Robert Jerris7Van Leung-Pineda8Mark D. Gonzalez9Beverly B. Rogers10Maud Mavigner11Raymond F. Schinazi12Nils Schoof13Jesse J. Waggoner14Russell R. Kempker15Paulina A. Rebolledo16Jared W. O’Neal17Cheryl Stone18Ann Chahroudi19Claudia R. Morris20Allie Suessmith21Julie Sullivan22Sarah Farmer23Amanda Foster24John D. Roback25Thanuja Ramachandra26CaDeidre Washington27Kristie Le28Maria C. Cordero29Annette Esper30Eric J. Nehl31Yun F. Wang32Erika A. Tyburski33Greg S. Martin34Wilbur A. Lam35Nell Hodgson Woodruff School of Nursing, Emory UniversityThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesThe Atlanta Center for Microsystems-Engineered Point-of-Care TechnologiesAbstract While there has been significant progress in the development of rapid COVID-19 diagnostics, as the pandemic unfolds, new challenges have emerged, including whether these technologies can reliably detect the more infectious variants of concern and be viably deployed in non-clinical settings as “self-tests”. Multidisciplinary evaluation of the Abbott BinaxNOW COVID-19 Ag Card (BinaxNOW, a widely used rapid antigen test, included limit of detection, variant detection, test performance across different age-groups, and usability with self/caregiver-administration. While BinaxNOW detected the highly infectious variants, B.1.1.7 (Alpha) first identified in the UK, B.1.351 (Beta) first identified in South Africa, P.1 (Gamma) first identified in Brazil, B.1.617.2 (Delta) first identified in India and B.1.2, a non-VOC, test sensitivity decreased with decreasing viral loads. Moreover, BinaxNOW sensitivity trended lower when devices were performed by patients/caregivers themselves compared to trained clinical staff, despite universally high usability assessments following self/caregiver-administration among different age groups. Overall, these data indicate that while BinaxNOW accurately detects the new viral variants, as rapid COVID-19 tests enter the home, their already lower sensitivities compared to RT-PCR may decrease even more due to user error.https://doi.org/10.1038/s41598-021-94055-1 |