Systemic compensatory response to neonatal estradiol exposure does not prevent depletion of the oocyte pool in the rat.

The formation of ovarian follicles is a finely tuned process that takes place within a narrow time-window in rodents. Multiple factors and pathways have been proposed to contribute to the mechanisms triggering this process but the role of endocrine factors, especially estrogens, remains elusive. It...

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Bibliographic Details
Main Authors: Clémentine Chalmey, Frank Giton, Frédéric Chalmel, Jean Fiet, Bernard Jégou, Séverine Mazaud-Guittot
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3864944?pdf=render