Molecular response to imatinib & its correlation with mRNA expression levels of imatinib influx & efflux transporters in patients with chronic myeloid leukaemia in chronic phase

Molecular response to imatinib & its correlation with mRNA expression levels of imatinib influx & efflux transporters in patients with chronic myeloid leukaemia in chronic phase

Background & objectives: Imatinib is the standard first-line treatment for chronic myeloid leukaemia (CML) patients. About 20 to 30 per cent patients develop resistance to imatinib and fail imatinib treatment. One of the mechanisms proposed is varying expression levels of the drug transporters....

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Bibliographic Details
Main Authors: Hemant Malhotra, Pratibha Sharma, Bharti Malhotra, Shipra Bhargava, Sandeep Jasuja, Madhu Kumar
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2015-01-01
Series:Indian Journal of Medical Research
Subjects:
ABCB1 - ABCG2 - chronic myeloid leukemia (CML) - chronic phase - imatinib - molecular response - mRNA expression - OCT1
Online Access:http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2015;volume=142;issue=2;spage=175;epage=182;aulast=Malhotra

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http://www.ijmr.org.in/article.asp?issn=0971-5916;year=2015;volume=142;issue=2;spage=175;epage=182;aulast=Malhotra

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