The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction

The Natural Compound Myricetin Effectively Represses the Malignant Progression of Prostate Cancer by Inhibiting PIM1 and Disrupting the PIM1/CXCR4 Interaction

Background/Aims: Natural compounds are a promising resource for anti-tumor drugs. Myricetin, an abundant flavonoid found in the bark and leaves of bayberry, shows multiple promising anti-tumor functions in various cancers. Methods: The cytotoxic, pro-apoptotic, and anti-metastatic effects of myricet...

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Bibliographic Details
Main Authors: Chen Ye, Chao Zhang, Hai Huang, Bo Yang, Guangan Xiao, Depei Kong, Qinqin Tian, Qixiang Song, Yunjie Song, Haisong Tan, Yang Wang, Tie Zhou, Xiaoyuan Zi, Yinghao Sun
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
Series:Cellular Physiology and Biochemistry
Subjects:
Prostate cancer
Myricetin
PIM1
CXCL12-CXCR4 axis
Small molecular inhibitor
Online Access:https://www.karger.com/Article/FullText/492009

Internet

https://www.karger.com/Article/FullText/492009

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