Bradykinin stimulation of nitric oxide production is not sufficient for gamma-globin induction

Bradykinin stimulation of nitric oxide production is not sufficient for gamma-globin induction

Introduction. Hydroxycarbamide, used in therapy of hemoglobinopathies, enhances nitric oxide (NO) production both in primary human umbilical vein endothelial cells (HUVECs) and human bone marrow endothelial cell line (TrHBMEC). Moreover, NO increases γ-globin and fetal hemoglobin levels in...

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Bibliographic Details
Main Authors: Čokić Vladan P., Subotički Tijana, Beleslin-Čokić Bojana, Diklić Miloš, Milenković Pavle, Jovčić Gordana
Format: Article
Language:English
Published: Serbian Medical Society 2014-01-01
Series:Srpski Arhiv za Celokupno Lekarstvo
Subjects:
bradykinin
endothelial cells
erythroid progenitors
nitric oxide
gamma-globin
Online Access:http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791404189C.pdf

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http://www.doiserbia.nb.rs/img/doi/0370-8179/2014/0370-81791404189C.pdf

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