Synthesis and Evaluation of 99mTc-Labeled Dimeric Folic Acid for FR-Targeting

Synthesis and Evaluation of 99mTc-Labeled Dimeric Folic Acid for FR-Targeting

The folate receptor (FR) is overexpressed in a wide variety of human tumors. In our study, the multimeric concept was used to synthesize a dimeric folate derivative via a click reaction. The novel folate derivative (HYNIC-D1-FA2) was radiolabeled with 99mTc using tricine and trisodium triphenylphosp...

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Bibliographic Details
Main Authors: Zhide Guo, Mengna Gao, Manli Song, Changrong Shi, Pu Zhang, Duo Xu, Linyi You, Rongqiang Zhuang, Xinhui Su, Ting Liu, Jin Du, Xianzhong Zhang
Format: Article
Language:English
Published: MDPI AG 2016-06-01
Series:Molecules
Subjects:
folate receptor
molecular imaging
dimeric folic acids
click reaction
SPECT imaging
Online Access:http://www.mdpi.com/1420-3049/21/6/817

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http://www.mdpi.com/1420-3049/21/6/817

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