The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine

The Unexpected Essentiality of glnA2 in Mycobacterium smegmatis Is Salvaged by Overexpression of the Global Nitrogen Regulator glnR, but Not by L-, D- or Iso-Glutamine

Nitrogen metabolism plays a central role in the physiology of microorganisms, and Glutamine Synthetase (GS) genes are present in virtually all bacteria. In M. tuberculosis, four GS genes are present, but only glnA1 is essential, whereas glnA2 was shown to be non-essential for in-vitro as well as in-...

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Bibliographic Details
Main Authors: Nadya Rakovitsky, Michal Bar Oz, Karin Goldberg, Simon Gibbons, Oren Zimhony, Daniel Barkan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Microbiology
Subjects:
mycobacteria
glutamine
glutamine synthetase
nitrogen
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02143/full

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https://www.frontiersin.org/article/10.3389/fmicb.2018.02143/full

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