Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.

Suppression of cytochrome p450 reductase enhances long-term hematopoietic stem cell repopulation efficiency in mice.

BACKGROUND: Bone marrow microenvironment (niche) plays essential roles in the fate of hematopoietic stem cells (HSCs). Intracellular and extracellular redox metabolic microenvironment is one of the critical factors for the maintenance of the niche. Cytochrome P450 reductase (CPR) is an obligate elec...

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Bibliographic Details
Main Authors: Yan Zhang, Fang Dong, Na Zhang, Hui Cheng, Yakun Pang, Xiaomin Wang, Jing Xu, Xinxin Ding, Tao Cheng, Jun Gu, Weiping Yuan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3724780?pdf=render

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http://europepmc.org/articles/PMC3724780?pdf=render

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